Postsynaptic block of frog neuromuscular transmission by conotoxin GI

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Postsynaptic block of frog neuromuscular transmission by conotoxin GI.

Conotoxin GI, a peptide neurotoxin contained in the venom of the marine snail Conus geographus, was applied to the cutaneous pectoris muscle of the frog, and the effects on the postsynaptic response to acetylcholine were examined. Conotoxin GI reversibly blocked nerve-evoked muscle contractions at concentrations greater than or equal to 3 to 4 microM. Micromolar concentrations of conotoxin GI s...

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Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission.

A long-held tenet of neuromuscular transmission is that calcium-dependent neurotransmitter release is mediated by N-type calcium channels in frog but P/Q-type channels in mammals. The N-type assignment in frog is based principally on pharmacological sensitivity to ω-conotoxin GVIA. Our studies show that zebrafish neuromuscular transmission is also sensitive to ω-conotoxin GVIA. However, positio...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1985

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.05-01-00110.1985